Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.56 |
| ▸ | FLT1 | P17948 | 4/20 | 0.56 |
| ▸ | FLT4 | P35916 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | STK10 | O94804 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616541 | 0.82 | HRH3 (0.43) | EGFRFGFR1SRCERBB2HRH3 | |
| SCHEMBL23450791 | 0.80 | EGFR (0.64) | EGFRKDRFLT1SRCERBB2 | |
| SCHEMBL8306485 | 0.80 | EGFR (0.53) | EGFRKDRFGFR1FLT1ERBB2 | |
| SCHEMBL8616544 | 0.80 | EGFR (0.58) | EGFRSRCERBB2HRH3MET | |
| SCHEMBL8305114 | 0.79 | EGFR (0.49) | EGFRKDRFLT1ERBB2BRAF | |
| SCHEMBL7763005 | 0.78 | EGFR (0.61) | EGFRKDRFLT1FLT4SRC | |
| SCHEMBL7864729 | 0.77 | KDR (0.73) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL8309481 | 0.77 | EGFR (0.50) | EGFRKDRFGFR1FLT1ERBB2 | |
| Hydrochloric Acid SCHEMBL7859457 | 0.77 | KDR (0.72) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL8308072 | 0.76 | EGFR (0.49) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | claimed |
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |