Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | VDR | P11473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13026882 | 0.78 | TDP1 (0.51) | TDP1LMNACASP3TP53ALDH1A1 | |
| SCHEMBL13026902 | 0.78 | TDP1 (0.51) | TDP1LMNACASP3TP53ALDH1A1 | |
| SCHEMBL7598734 | 0.74 | TDP1 (0.52) | TDP1LMNACASP3TP53ALDH1A1 | |
| SCHEMBL15042285 | 0.72 | TDP1 (0.50) | TDP1LMNACASP3TP53ALDH1A1 | |
| SCHEMBL29368754 | 0.71 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL64157 | 0.71 | ALDH1A1 (0.61) | LMNAALDH1A1MAPTKMT2AKDM4E | |
| SCHEMBL13829003 | 0.69 | HCAR2 (0.39) | TDP1LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL7277995 | 0.69 | TDP1 (0.47) | TDP1LMNACASP3TP53ALDH1A1 | |
| SCHEMBL28419506 | 0.69 | HCAR2 (0.39) | TDP1LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL13108155 | 0.69 | TDP1 (0.48) | TDP1LMNACASP3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0646116-B1 | PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5719286-A | Process and intermediates for bis-aza-bicyclic anxiolytic agents | PFIZER INC. (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0586376-B1 | Process and intermediates for the preparation of anxiolytic perhydro-1H-pyrido[1,2-a]pyrazines | PFIZER (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1995031572-A1 | AMINOHYDROCARBON PHOSPHONATE OLIGONUCLEOTIDES AND USES THEREFOR | PHARMGENICS, INC. (US) | 1995-11-23 | — | — | WO | disclosed |
| US-5455350-A | Process and intermediate for certain bis-aza-bicyclic anxiolytic agents | PFIZER INC. (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0573467-B1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO 1,2-a]PYRAZINES | PFIZER (US) | 1995-05-31 | — | — | EP | disclosed |
| EP-0646116-A1 | PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0586376-A1 | PROCESS AND INTERMEDIATE FOR CERTAIN BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS. | PFIZER (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1993025552-A1 | PROCESS AND INTERMEDIATES FOR BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |
| EP-0573467-A1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO 1,2-a]PYRAZINES. | PFIZER (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5185449-A | PROCESS AND INTERMEDIATE FOR CERTAIN BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1993-02-09 | — | — | US | disclosed |
| US-5157034-A | Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines | PFIZER INC. (US) | 1992-10-20 | — | — | US | disclosed |
| WO-1992015575-A1 | PROCESS AND INTERMEDIATE FOR CERTAIN BIS-AZA-BICYCLIC ANXIOLYTIC AGENTS | PFIZER INC. (US) | 1992-09-17 | — | — | WO | disclosed |
| WO-1992015580-A1 | NEUROLEPTIC PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES | PFIZER INC. (US) | 1992-09-17 | — | — | WO | disclosed |