SCHEMBL8310255

SCHEMBL8310255

COc1cc(C(=O)N(C)CC(CCS(C)(=O)=O)c2ccccc2F)cc(OC)c1OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KRAS P01116 2/20 0.40
ALDH1A1 P00352 2/20 0.39
LMNA P02545 1/20 0.39
TACR1 P25103 1/20 0.38
POLB P06746 1/20 0.38
ABCB1 P08183 1/20 0.38
ABCC1 P33527 1/20 0.38
TUBB4A P04350 5/20 0.37
TUBB P07437 5/20 0.37
TUBA3C P0DPH7 5/20 0.37
TUBA1B P68363 5/20 0.37
TUBA4A P68366 5/20 0.37
TUBB4B P68371 5/20 0.37
TUBB3 Q13509 5/20 0.37
TUBB2A Q13885 5/20 0.37
TUBB8 Q3ZCM7 5/20 0.37
TUBA3E Q6PEY2 5/20 0.37
TUBA1A Q71U36 5/20 0.37
TUBA1C Q9BQE3 5/20 0.37
TUBB6 Q9BUF5 5/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6597155 0.86 MAPK1 (0.42) ALDH1A1LMNATACR1POLBTUBB4A
SCHEMBL6596131 0.84 TUBB4A (0.40) KRASALDH1A1TUBB4ATUBBTUBA3C
SCHEMBL6591924 0.81 TUBB4A (0.43) KRASALDH1A1POLBTUBB4ATUBB
SCHEMBL6597573 0.80 TP53 (0.47) ALDH1A1LMNAPOLBTUBB4ATUBB
SCHEMBL6593722 0.80 LMNA (0.42) ALDH1A1LMNATACR1TUBB4ATUBB
SCHEMBL6595379 0.80 CCR5 (0.40) ALDH1A1LMNATACR1TUBB4ATUBB
SCHEMBL27503685 0.79 TACR1 (0.37) ALDH1A1TACR1POLBTUBB4ATUBB
SCHEMBL6596161 0.79 TACR1 (0.44) LMNATACR1
SCHEMBL6596708 0.79 L3MBTL1 (0.40) ALDH1A1LMNATACR1POLBTUBB1
SCHEMBL6597752 0.79 HSD17B10 (0.46) LMNAABCB1ABCC1TUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
EP-0888336-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)P IPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997030989-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL-AMINO)PIPERIDIN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed