Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7615608 | 0.80 | HTR2B (0.33) | ALDH1A1MCOLN3HPGD | |
| Bromide SCHEMBL7622203 | 0.80 | ALDH1A1 (0.31) | KMT2AALDH1A1MCOLN3HPGD | |
| Bromide SCHEMBL7880298 | 0.79 | MEN1 (0.43) | KMT2A | |
| Bromide SCHEMBL7880295 | 0.79 | MEN1 (0.43) | KMT2A | |
| Bromide SCHEMBL5198501 | 0.79 | HSD11B1 (0.42) | KMT2AALDH1A1MCOLN3 | |
| Bromide SCHEMBL5198499 | 0.79 | HSD11B1 (0.42) | KMT2AALDH1A1MCOLN3 | |
| Bromide SCHEMBL8779720 | 0.78 | POLB (0.37) | CYP2D6BRD4KMT2AALDH1A1 | |
| Bromide SCHEMBL7885589 | 0.77 | PIK3CD (0.50) | SMN1; SMN2TSHRALDH1A1MCOLN3 | |
| Bromide SCHEMBL7885592 | 0.77 | PIK3CD (0.50) | SMN1; SMN2TSHRALDH1A1MCOLN3 | |
| Bromide SCHEMBL8508757 | 0.76 | PER2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985905-A | USEFUL FOR THE TREATMENT AND/OR PROPHYLAXIS OF DISEASES ASSOCIATED WITH LOSS OF BONE MASS, SUCH AS OSTEOPOROSIS AND RELATED OSTEOPENIC DISEASES, PAGET'S DISEASE, HYPERPARATHYROIDISM AND RELATED DISEASES, ALSO ANTITUMOR | ENCYSIVE PHARMACEUTICALS, INC. | 1999-11-16 | — | — | US | disclosed |
| EP-0912560-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | Smithkline Beecham S.p.A. (IT) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001445-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |
| EP-0204964-B1 | 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |