Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 9/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8779755 | 0.85 | ALDH1A1 (0.34) | POLBACHEKMT2AALDH1A1 | |
| Bromide SCHEMBL7620592 | 0.79 | ALDH1A1 (0.49) | POLBCYP2D6CYP2C9ACHEKMT2A | |
| Bromide SCHEMBL8310683 | 0.78 | SRD5A1 (0.35) | CYP2D6KMT2ABRD4ALDH1A1 | |
| Bromide SCHEMBL8779660 | 0.75 | GPR119 (0.34) | KMT2A | |
| Bromide SCHEMBL8779704 | 0.75 | NPC1 (0.40) | — | |
| Bromide SCHEMBL7622203 | 0.75 | ALDH1A1 (0.31) | ACHEKMT2AALDH1A1 | |
| Bromide SCHEMBL7615608 | 0.75 | HTR2B (0.33) | ACHEALDH1A1 | |
| Bromide SCHEMBL7880298 | 0.74 | MEN1 (0.43) | POLBKMT2A | |
| Bromide SCHEMBL5198499 | 0.74 | HSD11B1 (0.42) | KMT2AALDH1A1 | |
| Bromide SCHEMBL5198501 | 0.74 | HSD11B1 (0.42) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525197-B1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOGS | SHIONOGI & CO (JP) | 1997-08-27 | — | — | EP | disclosed |
| US-5319100-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| US-5319099-A | Antiinflammatory agent which does not cause stomach diseases | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0525197-A1 | 3-BENZYLIDENE-1-CARBAMOYL-2-PYRROLIDONE ANALOG | SHIONOGI SEIYAKU KABUSHIKI KAISHA (JP) | 1993-02-03 | — | — | EP | disclosed |