Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300632 | 0.95 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3KCNH2JAK1 | |
| SCHEMBL8291783 | 0.92 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8292045 | 0.82 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2LMNA | |
| SCHEMBL8291779 | 0.82 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2JAK1 | |
| SCHEMBL13698254 | 0.75 | SLC6A4 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2LMNA | |
| SCHEMBL8298259 | 0.73 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8300797 | 0.72 | PDE4A (0.40) | SLC6A2SLC6A4SLC6A3KCNH2PDE4B | |
| SCHEMBL25758981 | 0.69 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3KCNH2TP53 | |
| SCHEMBL8558088 | 0.69 | PDE4A (0.39) | SLC6A2SLC6A4SLC6A3KCNH2PDE4B | |
| SCHEMBL8593208 | 0.67 | UTS2R (0.39) | SLC6A3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591040-B1 | Quaternary basic amides as tachykinines antagonists | SANOFI SA (FR) | 1999-02-03 | — | — | EP | disclosed |
| US-5712288-A | TACHYKININ ANTAGONIST, ANTIINFLAMMATORY, ANTIALLERGEN | SANOFI (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5679693-A | TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1997-10-21 | — | — | US | disclosed |
| US-5583134-A | QUATERNARY BASIC AMIDE DERIVATIVES; USEFUL FOR TREATING PATHOLOGICAL CONDITION INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1996-12-10 | — | — | US | disclosed |
| US-5554763-A | TACHYKININ ANTAGONISTS | SANOFI (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0591040-A1 | Quaternary basic amides as tachykinines antagonists | SANOFI (FR) | 1994-04-06 | — | — | EP | disclosed |