Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558088 | 0.90 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4DOPRM1 | |
| SCHEMBL8291783 | 0.72 | SLC6A2 (0.41) | SLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL8311113 | 0.72 | SLC6A2 (0.44) | PDE4BSLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL8300632 | 0.71 | SLC6A2 (0.46) | SLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL8292045 | 0.70 | SLC6A2 (0.38) | SLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL8564881 | 0.70 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DKCNA5 | |
| SCHEMBL8291779 | 0.69 | SLC6A4 (0.43) | SLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL8298259 | 0.69 | SLC6A2 (0.36) | OPRM1OPRK1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8558084 | 0.68 | PTAFR (0.37) | PDE4APDE4BPDE4CPDE4DTACR1 | |
| SCHEMBL7846543 | 0.67 | TACR1 (0.47) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |