Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311113 | 0.95 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2JAK1 | |
| SCHEMBL8291783 | 0.91 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8291779 | 0.87 | SLC6A4 (0.43) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL8292045 | 0.81 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2JAK1 | |
| SCHEMBL8298259 | 0.73 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2CYP2D6 | |
| SCHEMBL8300797 | 0.71 | PDE4A (0.40) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL13698254 | 0.69 | SLC6A4 (0.56) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL8558088 | 0.68 | PDE4A (0.39) | SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL8593208 | 0.68 | UTS2R (0.39) | SLC6A3CYP2D6 | |
| SCHEMBL8742506 | 0.67 | SIGMAR1 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | claimed |
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5770735-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present | ELF SANOFI (FR) | 1998-06-23 | — | — | US | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |