Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.51 |
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165667 | 0.82 | GPR119 (0.71) | GPR119LSSHPGDCKS1BSKP1 | |
| SCHEMBL3486872 | 0.81 | GPR119 (0.73) | GPR119LSS | |
| SCHEMBL8446403 | 0.80 | LSS (0.51) | LSSDGAT2GPBAR1EIF2AK4 | |
| SCHEMBL8289982 | 0.80 | LSS (0.65) | LSSHPGDCKS1BSKP1SKP2 | |
| SCHEMBL6975264 | 0.79 | GPR119 (0.54) | GPR119CKS1BSKP1SKP2 | |
| SCHEMBL7650536 | 0.78 | GPR119 (0.55) | GPR119LSSCKS1BSKP1SKP2 | |
| SCHEMBL8310078 | 0.76 | LSS (0.83) | LSSHPGD | |
| SCHEMBL6981587 | 0.75 | GPR119 (0.59) | GPR119HPGDCKS1BSKP1SKP2 | |
| SCHEMBL17637739 | 0.75 | GPBAR1 (0.51) | LSSHPGDGPBAR1 | |
| SCHEMBL7654759 | 0.74 | GPR119 (0.55) | GPR119CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |