Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.51 |
| ▸ | DGAT2 | Q96PD7 | 16/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.45 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289982 | 0.83 | LSS (0.65) | LSSGPBAR1F10 | |
| SCHEMBL8311310 | 0.80 | GPR119 (0.51) | LSSDGAT2GPBAR1EIF2AK4 | |
| SCHEMBL17637739 | 0.78 | GPBAR1 (0.51) | LSSGPBAR1 | |
| SCHEMBL6969578 | 0.78 | LSS (0.53) | LSSDGAT2GPBAR1 | |
| SCHEMBL8310078 | 0.75 | LSS (0.83) | LSS | |
| SCHEMBL6977620 | 0.74 | HRH3 (0.48) | LSS | |
| SCHEMBL8309729 | 0.74 | LSS (0.89) | LSSF10 | |
| SCHEMBL1777724 | 0.74 | LSS (0.52) | LSSDGAT2GPBAR1EIF2AK4F10 | |
| SCHEMBL4719330 | 0.73 | LSS (0.57) | LSSGPBAR1EIF2AK4F10 | |
| SCHEMBL7661376 | 0.72 | LSS (0.55) | LSSGPBAR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |