Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.40 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588859 | 0.89 | HDAC1 (0.44) | HDAC1HDAC8HDAC6HSD11B1KDM1A | |
| SCHEMBL14300919 | 0.86 | HSD11B1 (0.46) | HDAC1HDAC8HDAC6HSD11B1KDM1A | |
| SCHEMBL14272834 | 0.86 | HSD11B1 (0.46) | HDAC1HDAC8HDAC6HSD11B1KDM1A | |
| SCHEMBL1222691 | 0.85 | HSD11B1 (0.55) | HDAC1HDAC8HDAC6TACR1OPRD1 | |
| SCHEMBL5314419 | 0.85 | HSD11B1 (0.55) | HDAC1HDAC8HDAC6TACR1OPRD1 | |
| SCHEMBL5313407 | 0.85 | HSD11B1 (0.55) | HDAC1HDAC8HDAC6TACR1OPRD1 | |
| SCHEMBL8315315 | 0.85 | HSD11B1 (0.46) | HDAC1HDAC8HDAC6TACR1OPRD1 | |
| SCHEMBL8314335 | 0.84 | KDM1A (0.44) | HDAC1HDAC8HDAC6OPRD1OPRK1 | |
| SCHEMBL7623319 | 0.84 | KDM1A (0.44) | HDAC1HDAC8HDAC6OPRD1OPRK1 | |
| SCHEMBL14530296 | 0.81 | OPRD1 (0.54) | HDAC1HDAC8HDAC6OPRD1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |