Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.44 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | MCHR2 | Q969V1 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7623319 | 1.00 | KDM1A (0.44) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL31693878 | 0.91 | P2RX7 (0.44) | NAE1UBA3OPRD1OPRK1IDO1 | |
| SCHEMBL12084830 | 0.90 | KDM1A (0.46) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL12385458 | 0.84 | MCHR2 (0.50) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL8311424 | 0.84 | HDAC1 (0.44) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL2758247 | 0.84 | KDM4E (0.50) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL2758260 | 0.84 | NAE1 (0.46) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL14300912 | 0.83 | MCHR2 (0.43) | MCHR2 | |
| SCHEMBL2758261 | 0.82 | KDM1A (0.46) | KDM1AHDAC1HDAC8HDAC6NAE1 | |
| SCHEMBL8314152 | 0.82 | NAE1 (0.47) | KDM1AHDAC1HDAC8HDAC6NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329673-B2 | Acylated spiropiperidine derivatives as melanocortin-4 receptor agonists | MERCK & CO., INC. (US) | 2008-02-12 | — | — | US | disclosed |
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994019367-A1 | SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |