Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310464 | 0.86 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL8314327 | 0.86 | ABCC9 (0.40) | HTR2BSIGMAR1ABCC9ABCC8KCNJ11 | |
| SCHEMBL8310409 | 0.85 | ABCC9 (0.39) | HTR2BHTR7ABCC9ABCC8KCNJ11 | |
| SCHEMBL8312815 | 0.85 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8PGR | |
| SCHEMBL8316384 | 0.84 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8315406 | 0.83 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8314966 | 0.83 | KDM4E (0.39) | HTR2BTMEM97SIGMAR1HTR7ABCC9 | |
| SCHEMBL8315805 | 0.83 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8313863 | 0.83 | ABCC9 (0.38) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8310333 | 0.82 | ABCC9 (0.39) | HTR2BABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | claimed |
| EP-0626954-A1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GmbH (DE) | 1994-12-07 | — | — | EP | claimed |
| WO-1994013658-A2 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1994-06-23 | — | — | WO | claimed |
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5652252-A | POTASSIUM CHANNEL ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-07-29 | — | — | US | disclosed |
| US-5602152-A | POTASSIUM CHANNEL MODULATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |
| EP-0626954-A1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GmbH (DE) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994013658-A2 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1994-06-23 | — | — | WO | disclosed |