Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.60 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.60 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.60 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315809 | 0.91 | ABCC9 (0.60) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL6369348 | 0.84 | ABCC9 (0.62) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8310464 | 0.84 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8314327 | 0.84 | ABCC9 (0.40) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8312815 | 0.83 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8310409 | 0.83 | ABCC9 (0.39) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8315817 | 0.83 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8312379 | 0.83 | ABCC9 (0.45) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8316384 | 0.82 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8OPRD1 | |
| SCHEMBL8311451 | 0.82 | HTR2B (0.39) | ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | claimed |
| EP-0626954-A1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GmbH (DE) | 1994-12-07 | — | — | EP | claimed |
| WO-1994013658-A2 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1994-06-23 | — | — | WO | claimed |
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5652252-A | POTASSIUM CHANNEL ACTIVATORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-07-29 | — | — | US | disclosed |
| US-5602152-A | POTASSIUM CHANNEL MODULATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |
| EP-0626954-A1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GmbH (DE) | 1994-12-07 | — | — | EP | disclosed |
| WO-1994013658-A2 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1994-06-23 | — | — | WO | disclosed |