Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | PARL | Q9H300 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490844 | 0.74 | PARL (0.41) | ALDH1A1KMT2ACYP11B1CYP11B2KCNN4 | |
| SCHEMBL16118618 | 0.69 | PIK3CD (0.36) | — | |
| SCHEMBL29829993 | 0.68 | GSK3A (0.44) | CYP1A2CYP2C9CYP2C19KMT2ACYP11B1 | |
| SCHEMBL6368612 | 0.67 | MGLL (0.44) | ALDH1A1CYP11B1CYP11B2KCNN4 | |
| SCHEMBL6367771 | 0.67 | MEN1 (0.48) | ALDH1A1MAOACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7599986 | 0.67 | PIK3CD (0.44) | KMT2AKCNN4 | |
| SCHEMBL28363952 | 0.64 | KMT2A (0.38) | ALDH1A1KMT2A | |
| SCHEMBL8735062 | 0.63 | CYP1A2 (0.48) | ALDH1A1CYP1A2KMT2APARL | |
| SCHEMBL7131427 | 0.63 | ELANE (0.53) | ALDH1A1KMT2A | |
| SCHEMBL9844592 | 0.63 | CYP2B6 (0.32) | CYP2B6CYP11B1CYP11B2KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0597102-B1 | NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF AND HYPOGLYCEMIC COMPOSITION | YAMANOUCHI PHARMA CO LTD (JP) | 1999-01-07 | — | — | EP | disclosed |
| US-5508296-A | HYPOGLYCEMIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| US-5498621-A | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0537300-B1 | Oxazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0428312-B1 | Oxazolidinedione hypoglycemic agents | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0597102-A1 | NOVEL BISHETEROCYCLIC DERIVATIVE OR SALT THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1994-05-18 | — | — | EP | disclosed |
| EP-0537300-A1 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS. | PFIZER (US) | 1993-04-21 | — | — | EP | disclosed |
| WO-1991019704-A2 | OXA- AND THIAZOLIDINEDIONE HYPOGLYCEMIC AND HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5037842-A | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents | PFIZER INC. (US) | 1991-08-06 | — | — | US | disclosed |
| WO-1991007107-A1 | OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-05-30 | — | — | WO | disclosed |
| EP-0428312-A2 | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1991-05-22 | — | — | EP | disclosed |