SCHEMBL8312265

SCHEMBL8312265

N#CCCCNc1nc2c(Cl)cc(F)c(N)c2s1

nearest known ligand 0.31

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
PGK1 P00558 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8310210 0.83 ABL1 (0.36) KDM4EMEN1LMNAPOLBMAPT
SCHEMBL8310259 0.81
SCHEMBL8312267 0.73 KDM4E (0.34) KDM4EKMT2A
SCHEMBL8313967 0.72 MAPK14 (0.38) KDM4EMEN1LMNAPOLBMAPT
SCHEMBL9148367 0.70 SMN1; SMN2 (0.38) KDM4EMEN1LMNAPOLBMAPT
SCHEMBL8312415 0.69 SMN1; SMN2 (0.37) KDM4EMEN1LMNAPOLBMAPT
Hydrochloric Acid SCHEMBL9147162 0.69 SMN1; SMN2 (0.37) KDM4EMEN1LMNAPOLBMAPT
SCHEMBL8334566 0.68 TLR8 (0.36) KDM4EMEN1LMNAPOLBMAPT
SCHEMBL8329490 0.67 TLR8 (0.40)
SCHEMBL8331898 0.65 KDR (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958295-A1 SUBSTITUTED 2-(2,4(1H,3H)-PYRIMIDINDION-3-YL) BENZTHIAZOLES BASF AKTIENGESELLSCHAFT (DE) 1999-11-24 EP disclosed
WO-1998033796-A1 SUBSTITUTED 2-(2,4(1H,3H)-PYRIMIDINDION-3-YL) BENZTHIAZOLES BASF AKTIENGESELLSCHAFT (DE) 1998-08-06 WO disclosed