SCHEMBL8329490

SCHEMBL8329490

CCc1nc2c(Cl)cc(F)c(N)c2s1

nearest known ligand 0.40

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 5/20 0.40
TLR7 Q9NYK1 5/20 0.40
GAA P10253 2/20 0.35
NPC1 O15118 1/20 0.35
MAPK1 P28482 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.33
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8334566 0.80 TLR8 (0.36) TLR8TLR7NPC1MAPK1RAB9A
SCHEMBL9148367 0.79 SMN1; SMN2 (0.38) GAASMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL8312415 0.78 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL9147162 0.78 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1
SCHEMBL8332254 0.76 ALDH1A1 (0.36) TLR8TLR7GAANPC1MAPK1
SCHEMBL8331898 0.76 KDR (0.36) SMN1; SMN2ALDH1A1
SCHEMBL8310400 0.76 MAPT (0.36) GAASMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL8313967 0.75 MAPK14 (0.38) TLR8TLR7
SCHEMBL8310210 0.74 ABL1 (0.36) TLR8NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL8333788 0.74 SMN1; SMN2 (0.32) SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5888940-A DESICCATING PLANTS BASF AKTIENGESELLSCHAFT (DE) 1999-03-30 US disclosed
CN-1194645-A Substituted benzothiazols with herbicidal action BASF AG (DE) 1998-09-30 CN disclosed
EP-0862569-A1 SUBSTITUTED BENZOTHIAZOLS WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1998-09-09 EP disclosed
WO-1997008171-A1 SUBSTITUTED BENZOTHIAZOLS WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1997-03-06 WO disclosed