Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763472 | 0.69 | ALDH1A1 (0.47) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL8315752 | 0.69 | MEN1 (0.39) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL29776965 | 0.67 | B3GNT2 (0.43) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6394776 | 0.67 | ALDH1A1 (0.67) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL8317250 | 0.67 | ALDH1A1 (0.32) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL9739218 | 0.63 | ALDH1A1 (0.43) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL11637797 | 0.60 | KDM4E (0.77) | HSD17B10KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL4767676 | 0.60 | B3GNT2 (0.43) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL11429505 | 0.59 | RGS4 (0.50) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 | |
| SCHEMBL20853011 | 0.59 | CCR2 (0.38) | SMN1; SMN2TSHRHSD17B10TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |