Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318390 | 0.76 | CYP11B2 (0.31) | MEN1KMT2A | |
| SCHEMBL8316729 | 0.74 | ALDH1A1 (0.50) | ALDH1A1POLBSMN1; SMN2TSHRLMNA | |
| SCHEMBL2474620 | 0.70 | HTR2A (0.32) | ALDH1A1SMN1; SMN2TDP1LMNAMEN1 | |
| SCHEMBL8312333 | 0.67 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL20853011 | 0.66 | CCR2 (0.38) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL1735362 | 0.65 | DYRK1A (0.37) | ALDH1A1POLBSMN1; SMN2TSHRHSD17B10 | |
| SCHEMBL19448730 | 0.61 | CCR9 (0.39) | ALDH1A1POLBLMNAMAPTCYP1A2 | |
| SCHEMBL10147189 | 0.61 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL21233348 | 0.60 | TDP1 (0.35) | ALDH1A1SMN1; SMN2TSHRHSD17B10TDP1 | |
| SCHEMBL8315752 | 0.59 | MEN1 (0.39) | ALDH1A1POLBSMN1; SMN2TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |