Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MMP13 | P45452 | 5/20 | 0.36 |
| ▸ | MMP1 | P03956 | 3/20 | 0.36 |
| ▸ | MMP9 | P14780 | 3/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.35 |
| ▸ | MMP8 | P22894 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6267605 | 0.94 | MMP13 (0.37) | RORCKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL6230548 | 0.93 | MMP13 (0.41) | RORCKDM4EKMT2AMEN1NPC1 | |
| SCHEMBL8312513 | 0.92 | MMP13 (0.45) | RORCMMP13MMP1MMP9ADAM17 | |
| SCHEMBL6278357 | 0.91 | MMP8 (0.46) | RORCMMP13MMP1MMP9MMP2 | |
| SCHEMBL6234746 | 0.90 | MMP2 (0.44) | RORCKMT2AALDH1A1MMP13MMP1 | |
| SCHEMBL6276528 | 0.89 | ALDH1A1 (0.37) | RORCKMT2AMEN1NPC1HPGD | |
| SCHEMBL6230523 | 0.88 | MMP2 (0.46) | RORCKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6231050 | 0.88 | ALDH1A1 (0.34) | KDM4EKMT2ASMN1; SMN2ALDH1A1MMP13 | |
| SCHEMBL6231944 | 0.88 | ALDH1A1 (0.39) | KDM4EKMT2AMEN1NPC1HPGD | |
| SCHEMBL6229096 | 0.85 | MMP2 (0.44) | KMT2ASMN1; SMN2ALDH1A1MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |