SCHEMBL8312863

SCHEMBL8312863

CC1(C)C=C(c2ccccn2)c2cc(Cl)ccc2OC1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.39
NPC1 O15118 4/20 0.39
RAB9A P51151 4/20 0.39
ALDH1A1 P00352 2/20 0.39
PKM P14618 2/20 0.39
GRM5 P41594 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 2/20 0.38
KDM4E B2RXH2 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
CHRM1 P11229 1/20 0.37
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
HTT P42858 2/20 0.36
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8316296 0.86 CCR1 (0.35) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8315486 0.86 NPC1 (0.39) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8315585 0.85 ADRA1A (0.40) MAPTNPC1RAB9APKMGRM5
SCHEMBL8314584 0.85 FABP6 (0.37) MAPTRAB9AGRM5METAP2METAP1
SCHEMBL8316184 0.84 KDM4E (0.37) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8310381 0.84 HTR2B (0.40) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8314548 0.83 NPC1 (0.35) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8313611 0.83 NPC1 (0.41) MAPTNPC1RAB9AALDH1A1PKM
SCHEMBL8310538 0.83 GABRA1 (0.34) MAPTNPC1RAB9APKMSMN1; SMN2
SCHEMBL8313795 0.83 CCR1 (0.38) MAPTNPC1RAB9AALDH1A1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0626954-B1 BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES MERCK PATENT GMBH (DE) 1999-03-17 EP disclosed
US-5602152-A POTASSIUM CHANNEL MODULATOR MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1997-02-11 US disclosed
WO-1994013658-A2 BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES MERCK PATENT GMBH (DE) 1994-06-23 WO disclosed