Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9162699 | 1.00 | ALDH1A1 (0.42) | ALDH1A1KDM4EMTNR1AMTNR1BATM | |
| SCHEMBL27258760 | 0.89 | MTNR1A (0.44) | ALDH1A1KDM4EMTNR1AMTNR1BATM | |
| SCHEMBL3126064 | 0.84 | RAB9A (0.35) | ALDH1A1KDM4ECCR2KDM1AL3MBTL1 | |
| SCHEMBL1114461 | 0.82 | CCR2 (0.54) | ALDH1A1KDM4ECCR2CA1CA2 | |
| SCHEMBL8325782 | 0.80 | BTK (0.51) | CCR2KDM1ACA1CA2L3MBTL1 | |
| SCHEMBL7097599 | 0.80 | BTK (0.51) | CCR2KDM1ACA1CA2L3MBTL1 | |
| SCHEMBL3319000 | 0.79 | CCR2 (0.55) | ALDH1A1CCR2CA1CA2CA12 | |
| SCHEMBL23570889 | 0.78 | IDO1 (0.43) | ALDH1A1KDM4EMTNR1AMTNR1BATM | |
| SCHEMBL3748178 | 0.78 | IDO1 (0.43) | ALDH1A1KDM4EMTNR1AMTNR1BATM | |
| SCHEMBL8297582 | 0.78 | OR51E2 (0.38) | CCR2KDM1AOR51E2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | claimed |
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| EP-0462949-B1 | 1-alkyl-3-(acylamino)-epsilon-caprolactames as enhancers of learning and memory and pharmaceutical compositions containing same | SIGMA TAU IND FARMACEUTI (IT) | 1995-12-06 | — | — | EP | disclosed |
| EP-0462948-B1 | Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning and memory | SIGMA TAU IND FARMACEUTI (IT) | 1995-01-11 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5166150-A | Cognition activators | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1992-11-24 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0462948-A2 | Pharmaceutical compositions comprising 3-amino-epsilon-caprolactames for enhancing learning and memory | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1991-12-27 | — | — | EP | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |