Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311616 | 0.81 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2POLBNR1H2 | |
| SCHEMBL8318110 | 0.77 | MIF (0.42) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL8313251 | 0.65 | CASP3 (0.36) | NPC1RAB9ASMN1; SMN2POLBLMNA | |
| SCHEMBL956524 | 0.64 | ALKBH1 (0.55) | POLBMEN1KMT2A | |
| SCHEMBL10038830 | 0.62 | GAA (0.39) | RAB9ASMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL6298740 | 0.60 | POLB (0.41) | POLBMEN1KMT2ACYP2C19LMNA | |
| SCHEMBL951965 | 0.59 | MEN1 (0.51) | NPC1RAB9APOLBMEN1KMT2A | |
| SCHEMBL5847847 | 0.59 | MIF (0.44) | POLBMEN1KMT2ACYP2D6CYP2C19 | |
| SCHEMBL5848990 | 0.59 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2POLBMEN1 | |
| SCHEMBL4326158 | 0.58 | CYP2D6 (0.46) | MEN1KMT2ACYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |