Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5847847 | 0.80 | MIF (0.44) | MIFALDH1A1NPSR1MEN1PDE5A | |
| SCHEMBL5848990 | 0.80 | ALDH1A1 (0.51) | MIFALDH1A1NPSR1MEN1PDE5A | |
| SCHEMBL8311616 | 0.80 | SMN1; SMN2 (0.39) | ALDH1A1CYP1A2CYP2C9TSHRCYP2C19 | |
| SCHEMBL951965 | 0.77 | MEN1 (0.51) | MIFALDH1A1NPSR1MEN1PDE5A | |
| SCHEMBL8313152 | 0.77 | NPC1 (0.36) | ALDH1A1MEN1CYP2D6TSHRCYP2C19 | |
| SCHEMBL955510 | 0.75 | MIF (0.50) | MIFALDH1A1NPSR1MEN1PDE5A | |
| SCHEMBL952535 | 0.75 | MIF (0.43) | MIFALDH1A1NPSR1MEN1PDE5A | |
| Hydrochloric Acid SCHEMBL955004 | 0.74 | MIF (0.42) | MIFALDH1A1NPSR1MEN1PDE5A | |
| SCHEMBL8313251 | 0.74 | CASP3 (0.36) | ALDH1A1NPSR1CYP1A2TSHRKDM4E | |
| SCHEMBL7376604 | 0.73 | PDE5A (0.71) | MIFALDH1A1NPSR1MEN1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |