Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TPMT | P51580 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200068 | 0.82 | CASP6 (0.55) | CASP6TSHRLMNAHCAR3ALDH1A1 | |
| SCHEMBL7232490 | 0.77 | TSHR (0.45) | TSHRVCAM1ALDH1A1 | |
| SCHEMBL3146159 | 0.76 | CASP6 (0.60) | CASP6TSHRLMNAVCAM1HCAR3 | |
| SCHEMBL29105507 | 0.76 | GPR35 (0.48) | TSHRLMNAALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10571715 | 0.74 | CASP6 (0.58) | CASP6TSHRLMNAVCAM1HCAR3 | |
| 4-Chloro-3-Nitrobenzoic Acid SCHEMBL6101 | 0.71 | VCAM1 (0.77) | CASP6TSHRLMNAVCAM1HCAR3 | |
| SCHEMBL29111608 | 0.71 | CASP6 (0.55) | CASP6TSHRLMNAVCAM1HCAR3 | |
| 4-Chloro-3-Nitrobenzoic Acid SCHEMBL30234086 | 0.71 | VCAM1 (0.77) | CASP6TSHRLMNAVCAM1HCAR3 | |
| SCHEMBL30629252 | 0.71 | CASP6 (0.55) | CASP6TSHRLMNAVCAM1HCAR3 | |
| 4-Chloro-3-Nitrobenzoic Acid SCHEMBL8028245 | 0.70 | VCAM1 (0.74) | CASP6TSHRLMNAVCAM1HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061652-C | Endotheliomycine receptor antagonist | MERCK PATENT GMBH (DE) | 2001-02-07 | — | — | CN | disclosed |
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5821256-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-10-13 | — | — | US | disclosed |
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| US-5700807-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-23 | — | — | US | disclosed |
| CN-1156146-A | Endothelins receptor antagonist | MERCK PATENT GMBH (DE) | 1997-08-06 | — | — | CN | disclosed |
| CN-1155539-A | Endothelin receptor antagonists | MERCK PATENT GMBH (DE) | 1997-07-30 | — | — | CN | disclosed |
| CN-1149583-A | Enderma agent receptor antagonist | MERCK PATENT GMBH (DE) | 1997-05-14 | — | — | CN | disclosed |
| EP-0758650-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-19 | — | — | EP | disclosed |
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |
| CN-1141919-A | Endotheliomycine receptor antagonist | MOOK PATENT AG (DE) | 1997-02-05 | — | — | CN | disclosed |
| EP-0755934-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-01-29 | — | — | EP | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |