SCHEMBL8313376 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	MMP13	P45452	14/20	0.46

▸	MMP1	P03956	1/20	0.40

▸	CYP1A2	P05177	1/20	0.39

▸	CYP3A4	P08684	1/20	0.39

▸	CYP2D6	P10635	1/20	0.39

▸	MMP2	P08253	1/20	0.39

▸	MMP9	P14780	1/20	0.39

▸	RARB	P10826	2/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6207817	0.85	MMP13 (0.48)	MMP13MMP1CYP1A2CYP3A4CYP2D6
SCHEMBL6206170	0.78	L3MBTL1 (0.47)	MMP13CYP1A2CYP3A4CYP2D6RARB
SCHEMBL6205985	0.77	CYP2D6 (0.49)	MMP13MMP1CYP1A2CYP3A4CYP2D6
SCHEMBL6207339	0.75	MMP13 (0.49)	MMP13MMP1CYP1A2CYP3A4CYP2D6
SCHEMBL8313400	0.72	MMP13 (0.34)	MMP13
SCHEMBL14569172	0.72	NPC1 (0.50)	MMP13MMP1CYP1A2CYP3A4CYP2D6
SCHEMBL8312489	0.72	CA2 (0.34)	—
SCHEMBL5908698	0.71	CA12 (0.43)	MMP13MMP1MMP9RARB
SCHEMBL3255184	0.71	NPC1 (0.49)	MMP13MMP1CYP1A2CYP3A4CYP2D6
SCHEMBL3255085	0.70	MMP13 (0.49)	MMP13MMP1MMP2MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2004048368-A2	HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS	PHARMACIA CORPORATION (US)	2004-06-10	—	—	WO	disclosed