Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314913 | 0.93 | KMT2A (0.37) | MEN1KMT2APOLBMAPK1HRH3 | |
| SCHEMBL8317229 | 0.88 | KMT2A (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8314698 | 0.85 | SMN1; SMN2 (0.35) | MEN1KMT2APOLBSMN1; SMN2P2RX7 | |
| SCHEMBL8316844 | 0.84 | KMT2A (0.37) | MEN1KMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8315440 | 0.82 | KMT2A (0.39) | MEN1KMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8314818 | 0.82 | KMT2A (0.37) | MEN1KMT2APOLBMAPK1HRH3 | |
| SCHEMBL8316443 | 0.82 | KMT2A (0.48) | MEN1KMT2APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8875891 | 0.81 | POLB (0.41) | MEN1KMT2APOLBMAPK1SMN1; SMN2 | |
| SCHEMBL9536573 | 0.80 | MEN1 (0.43) | MEN1KMT2APOLBMAPK1SMN1; SMN2 | |
| SCHEMBL8316152 | 0.79 | POLB (0.37) | MEN1KMT2APOLBSMN1; SMN2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |