Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316152 | 0.94 | POLB (0.37) | SMN1; SMN2GAAALOX12L3MBTL1P2RX7 | |
| SCHEMBL8313613 | 0.85 | MEN1 (0.36) | SMN1; SMN2GAAALOX12P2RX7MEN1 | |
| SCHEMBL8316830 | 0.83 | KMT2A (0.43) | SMN1; SMN2P2RX7MEN1KMT2ATSHR | |
| SCHEMBL8317692 | 0.83 | POLB (0.35) | SMN1; SMN2GAAALOX12L3MBTL1P2RX7 | |
| SCHEMBL8876405 | 0.82 | MDM2 (0.40) | SMN1; SMN2GAAALOX12L3MBTL1P2RX7 | |
| SCHEMBL9536076 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2GAAALOX12L3MBTL1MEN1 | |
| SCHEMBL8317229 | 0.81 | KMT2A (0.38) | SMN1; SMN2GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL8316807 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2GAAALOX12L3MBTL1P2RX7 | |
| SCHEMBL8317561 | 0.80 | CYP3A4 (0.35) | SMN1; SMN2GAAALOX12L3MBTL1P2RX7 | |
| SCHEMBL8314913 | 0.79 | KMT2A (0.37) | GAAMEN1KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |