Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317229 | 0.93 | KMT2A (0.38) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8317105 | 0.89 | KMT2A (0.48) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8314913 | 0.89 | KMT2A (0.37) | KMT2AGAAMEN1ALDH1A1KDM4E | |
| SCHEMBL9696118 | 0.87 | SMN1; SMN2 (0.38) | KMT2AGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8315832 | 0.83 | KMT2A (0.38) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8316443 | 0.82 | KMT2A (0.48) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8876977 | 0.82 | KMT2A (0.44) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8313613 | 0.82 | MEN1 (0.36) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8316152 | 0.82 | POLB (0.37) | KMT2AGAASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8313446 | 0.80 | KMT2A (0.37) | KMT2AGAASMN1; SMN2MEN1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |