Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313613 | 0.93 | MEN1 (0.36) | KMT2AMEN1HRH3POLBALDH1A1 | |
| SCHEMBL8315440 | 0.89 | KMT2A (0.39) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL8316152 | 0.86 | POLB (0.37) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL8315832 | 0.85 | KMT2A (0.38) | KMT2AMEN1POLBALDH1A1HPGD | |
| SCHEMBL9536573 | 0.83 | MEN1 (0.43) | KMT2AMEN1POLBHPGDMAPK1 | |
| SCHEMBL8317105 | 0.83 | KMT2A (0.48) | KMT2AMEN1POLBALDH1A1GAA | |
| SCHEMBL8317229 | 0.82 | KMT2A (0.38) | KMT2AMEN1ALDH1A1HPGDGAA | |
| SCHEMBL8878180 | 0.82 | POLB (0.40) | KMT2AMEN1HRH3POLBALDH1A1 | |
| SCHEMBL8314818 | 0.80 | KMT2A (0.37) | KMT2AMEN1HRH3POLBMAPK1 | |
| SCHEMBL8314698 | 0.79 | SMN1; SMN2 (0.35) | KMT2AMEN1POLBGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |