Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TYMS | P04818 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312892 | 0.85 | TYMS (0.58) | KDM4ETYMSTSHRALDH1A1KMT2A | |
| SCHEMBL8315752 | 0.76 | MEN1 (0.39) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9740097 | 0.76 | KDM4E (0.67) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8316752 | 0.72 | TYMS (0.45) | KDM4ECYP1A2CYP2C9CYP2C19TYMS | |
| SCHEMBL15426106 | 0.72 | KDM4E (1.00) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8313452 | 0.71 | ALDH1A1 (0.56) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21407925 | 0.68 | KDM4E (0.54) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13200852 | 0.68 | HTR3A (0.61) | KDM4EHSD17B10CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2475184 | 0.68 | TYMS (0.46) | KDM4ECYP1A2CYP2C9CYP2C19TYMS | |
| SCHEMBL8318381 | 0.68 | KMT2A (0.42) | KDM4ECYP1A2CYP2C9CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |