Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TYMS | P04818 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198861 | 0.74 | SMN1; SMN2 (0.61) | ALDH1A1MAPTLMNATYMSMAPK1 | |
| SCHEMBL7835720 | 0.72 | KMT2A (0.69) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL8313656 | 0.71 | KDM4E (0.56) | ALDH1A1MAPTLMNATYMSMAPK1 | |
| SCHEMBL4480638 | 0.71 | HPGD (0.66) | ALDH1A1MAPTLMNATYMSMAPK1 | |
| SCHEMBL8316729 | 0.71 | ALDH1A1 (0.50) | ALDH1A1MAPTLMNATYMSMAPK1 | |
| SCHEMBL14038766 | 0.69 | KMT2A (0.56) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL4490722 | 0.69 | KMT2A (0.64) | ALDH1A1MAPTLMNATYMSMAPK1 | |
| SCHEMBL31560452 | 0.67 | ALDH1A1 (0.57) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 | |
| SCHEMBL9453672 | 0.67 | GSK3A (0.57) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4392970 | 0.67 | LMNA (0.60) | ALDH1A1MAPTLMNAMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| EP-0609328-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1994-08-10 | — | — | EP | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |