Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 2/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.49 |
| ▸ | PDE1A | P54750 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313656 | 0.85 | KDM4E (0.56) | TYMSALDH1A1KDM4EMAPTTSHR | |
| SCHEMBL19434471 | 0.76 | PDE1B (0.58) | TYMSPDE1BPDE1CPDE1AALDH1A1 | |
| SCHEMBL8313591 | 0.75 | DCTPP1 (0.50) | TYMSPDE1BPDE1CPDE1AALDH1A1 | |
| SCHEMBL8316079 | 0.74 | TYMS (0.57) | TYMSPDE1BPDE1CPDE1AALDH1A1 | |
| SCHEMBL8315752 | 0.72 | MEN1 (0.39) | PDE1BPDE1CPDE1AALDH1A1KDM4E | |
| SCHEMBL20187532 | 0.72 | CYP11B2 (0.47) | TYMSKDM4EMAPTPIK3R1PIK3CA | |
| SCHEMBL2475307 | 0.71 | ALDH1A1 (0.51) | TYMSPDE1BPDE1CPDE1AALDH1A1 | |
| SCHEMBL10758186 | 0.69 | DAO (0.47) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL4769071 | 0.69 | ALDH1A1 (0.60) | TYMSPDE1BPDE1CPDE1AALDH1A1 | |
| SCHEMBL8311879 | 0.68 | GABRA1 (0.44) | TYMSPDE1BPDE1CPDE1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | claimed |
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |