Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314227 | 1.00 | MAOB (0.37) | MAOBMAPK9MAPKAPK2TSHRADRA2A | |
| SCHEMBL8310785 | 0.92 | RAB9A (0.38) | MAOBMAPK9MAPKAPK2TSHRADRA2A | |
| SCHEMBL8310781 | 0.92 | RAB9A (0.38) | MAOBMAPK9MAPKAPK2TSHRADRA2A | |
| Oxalic Acid SCHEMBL8315279 | 0.86 | ALDH1A1 (0.37) | MAOBMAPK9MAPKAPK2TSHRADRA2A | |
| Oxalic Acid SCHEMBL8315277 | 0.86 | ALDH1A1 (0.37) | MAOBMAPK9MAPKAPK2TSHRADRA2A | |
| SCHEMBL8317159 | 0.84 | SMN1; SMN2 (0.38) | MAOBTSHRMAOAALDH1A1MAPT | |
| SCHEMBL8317162 | 0.84 | SMN1; SMN2 (0.38) | MAOBTSHRMAOAALDH1A1MAPT | |
| SCHEMBL8316008 | 0.79 | FGF23 (0.36) | NISCHMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8316004 | 0.79 | FGF23 (0.36) | NISCHMAPTLMNATP53SMN1; SMN2 | |
| SCHEMBL8313753 | 0.79 | KDM4E (0.34) | MAOBALDH1A1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |