Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317159 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4ERAB9ACYP3A4NPC1 | |
| SCHEMBL8317005 | 0.93 | KDM4E (0.42) | SMN1; SMN2KDM4ERAB9ACYP3A4NPC1 | |
| SCHEMBL8317001 | 0.93 | KDM4E (0.42) | SMN1; SMN2KDM4ERAB9ACYP3A4NPC1 | |
| SCHEMBL8314229 | 0.84 | MAOB (0.37) | SMN1; SMN2KDM4ERAB9ANPC1HPGD | |
| SCHEMBL8314227 | 0.84 | MAOB (0.37) | SMN1; SMN2KDM4ERAB9ANPC1HPGD | |
| SCHEMBL8315262 | 0.81 | PARP1 (0.46) | KDM4ERAB9ANPC1CYP1A2HDAC6 | |
| SCHEMBL8315265 | 0.81 | PARP1 (0.46) | KDM4ERAB9ANPC1CYP1A2HDAC6 | |
| SCHEMBL8316305 | 0.81 | MAPT (0.42) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL8316303 | 0.81 | MAPT (0.42) | SMN1; SMN2RAB9ANPC1LMNAPKM | |
| SCHEMBL8316802 | 0.81 | ALDH1A3 (0.35) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |