SCHEMBL8314375

SCHEMBL8314375

Fc1ccc(CNC2CCN(Cc3ccc(F)c(F)c3)C2)cc1F

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
BCHE P06276 13/20 0.62
ACHE P22303 12/20 0.62
BACE1 P56817 12/20 0.62
SIGMAR1 Q99720 2/20 0.53
ALDH1A1 P00352 1/20 0.51
HTT P42858 1/20 0.51
CCR3 P51677 1/20 0.51
DRD2 P14416 2/20 0.50
DRD4 P21917 1/20 0.50
HTR2A P28223 1/20 0.50
DRD3 P35462 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1022187 0.78 SIGMAR1 (0.60) SIGMAR1ALDH1A1HTTCCR3DRD2
SCHEMBL22361722 0.78 CARM1 (0.49) BCHEACHEBACE1CCR3
SCHEMBL8311629 0.77 BCHE (0.67) BCHEACHEBACE1SIGMAR1
SCHEMBL17967858 0.77 ALDH1A1 (0.57) SIGMAR1ALDH1A1HTTDRD2DRD4
SCHEMBL8313501 0.76 BCHE (0.56) BCHEACHEBACE1
Hydrochloric Acid SCHEMBL1239207 0.75 ALDH1A1 (0.55) SIGMAR1ALDH1A1HTTDRD2DRD4
Hydrochloric Acid SCHEMBL1237435 0.75 ALDH1A1 (0.55) SIGMAR1ALDH1A1HTTDRD2DRD4
SCHEMBL4131291 0.75 ACHE (1.00) BCHEACHEBACE1
SCHEMBL5692288 0.75 ACHE (1.00) BCHEACHEBACE1
SCHEMBL4635732 0.75 ACHE (0.75) BCHEACHEBACE1SIGMAR1CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787716-B1 Isoprene derivatives NISSHIN FLOUR MILLING CO (JP) 1999-12-08 EP disclosed
US-5756475-A POLYISOPRENE MODIFIED WITH AMINE WITH ANTICANCER AGENTS NISSHIN FLOUR MILLING CO., LTD. (JP) 1998-05-26 US disclosed
EP-0787716-A1 Isoprene derivatives NISSHIN FLOUR MILLING CO., LTD. (JP) 1997-08-06 EP disclosed