SCHEMBL8314455

SCHEMBL8314455

COC(C)(CF)c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.44
ALDH1A1 P00352 4/20 0.41
TAAR1 Q96RJ0 2/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.39
CES1 P23141 1/20 0.38
KCNN4 O15554 2/20 0.38
CYP2C19 P33261 1/20 0.38
HIF1A Q16665 1/20 0.38
SLC6A2 P23975 1/20 0.37
ESR1 P03372 2/20 0.35
ESR2 Q92731 2/20 0.35
CYP3A4 P08684 1/20 0.35
GAA P10253 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1774346 0.86 MAPK1 (0.44) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL5832056 0.80 ALDH1A1 (0.45) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL487150 0.80 MAPK1 (0.43) MAPK1ALDH1A1TAAR1ALOX15CES1
SCHEMBL22529922 0.79 MAPK1 (0.39) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL13166557 0.78 MAPK1 (0.41) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL16673523 0.77 MAPK1 (0.40) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL7535477 0.77 ALDH1A1 (0.42) MAPK1ALDH1A1TAAR1ALOX15CES1
SCHEMBL31187336 0.75 SMN1; SMN2 (0.41) MAPK1ALDH1A1TAAR1ALOX15MEN1
SCHEMBL28605222 0.75 MAPK1 (0.39) MAPK1ALDH1A1TAAR1ALOX15TSHR
SCHEMBL11208770 0.74 MAPK1 (0.52) MAPK1ALDH1A1TAAR1ALOX15TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0741730-B1 1-SUBSTITUTED-4-FLUORO-1,4-DIAZONIABICYCLO 2.2.2]OCTANE SALTS AND THEIR APPLICATION AS FLUORINATING AGENTS ALLIED SIGNAL INC (US) 1999-10-06 EP disclosed
EP-0842177-A1 PROCESS FOR THE MANUFACTURE OF 1-SUBSTITUTED-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE SALTS AlliedSignal Inc. (US) 1998-05-20 EP disclosed
WO-1997042193-A1 PROCESS FOR THE MANUFACTURE OF 1-SUBSTITUTED-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE SALTS ALLIEDSIGNAL INC. (US) 1997-11-13 WO disclosed
US-5631372-A Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts ALLIEDSIGNAL INC. (US) 1997-05-20 US disclosed
US-5606084-A Process of fluorinating organic compounds with 1-substituted-4-fluoro-1,4-diazoniabicyclo octane salts ALLIEDSIGNAL INC. (US) 1997-02-25 US disclosed
EP-0741730-A1 1-SUBSTITUTED-4-FLUORO-1,4-DIAZONIABICYCLO 2.2.2]OCTANE SALTS AND THEIR APPLICATION AS FLUORINATING AGENTS AlliedSignal Inc. (US) 1996-11-13 EP disclosed
US-5459267-A 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts and their application as fluorinating agents ALLIEDSIGNAL INC. (US) 1995-10-17 US disclosed
WO-1995017404-A1 1-SUBSTITUTED-4-FLUORO-1,4-DIAZONIABICYCLO[2.2.2]OCTANE SALTS AND THEIR APPLICATION AS FLUORINATING AGENTS ALLIEDSIGNAL, INC. (US) 1995-06-29 WO disclosed
EP-0190393-B1 NOVEL PERFLUORO CHEMICALS AND POLYFLUORINATED COMPOUNDS AND PROCESS FOR PRODUCTION OF THE SAME GREEN CROSS CORPORATION (JP) 1989-11-15 EP disclosed
US-4868318-A SYNTHETIC BLOOD THE GREEN CROSS CORPORATION (JP) 1989-09-19 US disclosed
US-4686024-A Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same THE GREEN CROSS CORPORATION (JP) 1987-08-11 US disclosed
EP-0190393-A2 Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same GREEN CROSS CORPORATION (JP) 1986-08-13 EP disclosed