Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 9/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8319668 | 0.97 | CHRM2 (0.52) | CHRM2CHRM1CHRM3CHRM4S1PR5 | |
| SCHEMBL8313975 | 0.92 | CHRM2 (0.49) | CHRM2CHRM1CHRM3CHRM4HRH3 | |
| SCHEMBL8314558 | 0.82 | CHRM2 (0.55) | CHRM2 | |
| SCHEMBL8314793 | 0.76 | HRH3 (0.55) | CHRM2HRH3MEN1ALDH1A1CYP2D6 | |
| SCHEMBL8313001 | 0.76 | MEN1 (0.45) | CHRM2S1PR5HRH3MEN1ALDH1A1 | |
| SCHEMBL8315643 | 0.75 | CHRM2 (0.52) | CHRM2 | |
| SCHEMBL8314512 | 0.75 | CHRM2 (0.47) | CHRM2CHRM1CHRM4S1PR5HRH3 | |
| SCHEMBL8315477 | 0.72 | ALDH1A1 (0.51) | CHRM2MEN1ALDH1A1KMT2A | |
| SCHEMBL8791763 | 0.70 | PRKAA2 (0.56) | S1PR5HRH3MEN1ALDH1A1CYP2D6 | |
| SCHEMBL7409733 | 0.69 | S1PR5 (0.63) | S1PR5HRH3MEN1ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004066960-A2 | COMBINATION OF H1, H3 AND H4 RECEPTOR ANTAGONISTS FOR TREATMENT OF ALLERGIC AND NON-ALLERGIC PULMONARY INFLAMMATION, CONGESTION AND ALLERGIC RHINITIS | SCHERING CORPORATION (US) | 2004-08-12 | — | — | WO | disclosed |