Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772682 | 0.80 | KMT2A (0.57) | HTTKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL7829888 | 0.77 | HTT (0.53) | HTTKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL15670580 | 0.75 | HTT (0.51) | HTTKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL8312072 | 0.74 | KMT2A (0.67) | HTTKMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL17101127 | 0.72 | ALDH1A1 (0.61) | HTTKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL18754397 | 0.71 | HTT (0.58) | HTTKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL16506289 | 0.68 | HTT (0.54) | HTTKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL22275503 | 0.68 | HTT (0.50) | HTTALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL2420773 | 0.66 | KDM4E (0.54) | HTTKMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL21863678 | 0.66 | HTT (0.51) | HTTKMT2AALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |