Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 18/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5879323 | 0.80 | PTPRC (0.58) | CCNE2CDK4PRKACAPRKACGPRKACB | |
| SCHEMBL5879258 | 0.77 | CDK4 (0.49) | TDO2CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL28503581 | 0.76 | PTPN1 (0.55) | TDO2CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL7862532 | 0.75 | CDK4 (0.67) | TDO2CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL8001537 | 0.73 | PTPN1 (0.39) | — | |
| SCHEMBL9087145 | 0.72 | PRKCB (0.74) | CCNE2CDK4PRKACAPRKACGPRKACB | |
| 6-Fluoro-3-Phenylindole SCHEMBL3626834 | 0.71 | TDO2 (0.68) | TDO2IDO1GPR84 | |
| SCHEMBL16990332 | 0.70 | TDO2 (0.59) | TDO2IDO1 | |
| SCHEMBL5339298 | 0.70 | CDK4 (0.57) | TDO2CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL8317402 | 0.69 | SIRT2 (0.63) | TDO2CCNE2CDK4PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630242-B1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | WELLCOME FOUND (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5547976-A | VIRICIDES, HERPES VIRUS, CYTOMEGALOVIRUS; CARDIOVASCULAR DISORDERS | BURROUGHS WELLCOME CO. (US) | 1996-08-20 | — | — | US | disclosed |
| EP-0630242-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018766-A1 | FURTHER INDOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-09-30 | — | — | WO | disclosed |