SCHEMBL8314841

SCHEMBL8314841

Cc1cc(OCC2CC2(C)C(F)(F)F)nc(Oc2ccnc(C(F)(F)F)c2)c1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BLM P54132 1/20 0.34
LOX P28300 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.32
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
IDH1 O75874 1/20 0.31
TGFBR1 P36897 2/20 0.31
TRPV1 Q8NER1 1/20 0.31
RXRA P19793 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2B Q13224 1/20 0.31
CYP1A2 P05177 1/20 0.30
CYP2C9 P11712 1/20 0.30
SYK P43405 1/20 0.30
KDM4E B2RXH2 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8310332 0.80 BLM (0.36) BLMLOXLOXL2ALOX5APFEN1
SCHEMBL8310855 0.79 KMT2A (0.38) TGFBR1TRPV1
SCHEMBL6610030 0.73 BLM (0.37) BLMLOXLOXL2ALOX5APFEN1
SCHEMBL6612907 0.72 BLM (0.37) BLMLOXLOXL2ALOX5APFEN1
SCHEMBL6609150 0.72 BLM (0.36) BLMLOXLOXL2ALOX5APFEN1
SCHEMBL8481697 0.71 BLM (0.38) BLMLOXLOXL2CYP1A2CYP2C9
SCHEMBL8475227 0.71 CYP11B1 (0.36) BLMLOXLOXL2TGFBR1RXRA
SCHEMBL8126836 0.70 BLM (0.38) BLMLOXLOXL2ALOX5APFEN1
SCHEMBL6611166 0.69 BLM (0.34) BLMLOXLOXL2TGFBR1RXRA
SCHEMBL6609586 0.69 BLM (0.34) BLMLOXLOXL2ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0955292-A1 Herbicidal 2-(cycloalk(en)yloxy)-6-(hetero)aryloxy(thio)pyridines American Cyanamid Company (US) 1999-11-10 EP claimed
EP-0955292-A1 Herbicidal 2-(cycloalk(en)yloxy)-6-(hetero)aryloxy(thio)pyridines American Cyanamid Company (US) 1999-11-10 EP disclosed