Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6990835 | 0.90 | EGFR (0.50) | EGFR | |
| SCHEMBL6993872 | 0.85 | EGFR (0.69) | EGFR | |
| SCHEMBL8314880 | 0.84 | EGFR (0.53) | EGFR | |
| SCHEMBL8320084 | 0.84 | EGFR (0.70) | EGFR | |
| SCHEMBL8315330 | 0.84 | EGFR (0.57) | EGFR | |
| SCHEMBL6989584 | 0.84 | EGFR (0.47) | EGFRHDAC6 | |
| SCHEMBL6417047 | 0.84 | EGFR (0.66) | EGFR | |
| SCHEMBL8320237 | 0.83 | EGFR (0.55) | EGFR | |
| SCHEMBL8318188 | 0.82 | EGFR (0.55) | EGFR | |
| SCHEMBL6994593 | 0.82 | ABCG2 (0.54) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |