Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6993872 | 0.87 | EGFR (0.69) | EGFR | |
| SCHEMBL8314880 | 0.86 | EGFR (0.53) | EGFR | |
| SCHEMBL8315330 | 0.86 | EGFR (0.57) | EGFRMEN1ERBB2KMT2AMKNK1 | |
| SCHEMBL6417047 | 0.86 | EGFR (0.66) | EGFRMEN1ERBB2KMT2A | |
| SCHEMBL8315829 | 0.84 | EGFR (0.51) | EGFR | |
| SCHEMBL8320237 | 0.84 | EGFR (0.55) | EGFRMEN1KMT2ATNK2 | |
| SCHEMBL8318188 | 0.84 | EGFR (0.55) | EGFR | |
| SCHEMBL6994593 | 0.84 | ABCG2 (0.54) | EGFR | |
| SCHEMBL6990835 | 0.84 | EGFR (0.50) | EGFR | |
| SCHEMBL6995062 | 0.84 | EGFR (0.51) | EGFRERBB2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |