Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | FABP1 | P07148 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7703136 | 0.93 | LTA4H (0.46) | MAOBLTA4HTSHRGSTP1AKR1C3 | |
| SCHEMBL16719443 | 0.90 | PGR (0.40) | MAOBLTA4HTSHRGSTP1AKR1C3 | |
| SCHEMBL16719819 | 0.89 | LTA4H (0.42) | MAOBLTA4HTSHRAKR1C3MEN1 | |
| SCHEMBL8529939 | 0.87 | GSTP1 (0.47) | MAOBLTA4HTSHRGSTP1AKR1C3 | |
| SCHEMBL6131987 | 0.86 | MAOB (0.44) | MAOBLTA4HTSHRGSTP1AKR1C3 | |
| SCHEMBL2262764 | 0.84 | DHODH (0.35) | MAOBGSTP1FFAR1FFAR4GAA | |
| SCHEMBL8531550 | 0.82 | MAPT (0.40) | MAOBLTA4HTSHRGSTP1GAA | |
| SCHEMBL16719650 | 0.81 | NOTUM (0.39) | MAOBLTA4HTSHRGSTP1MAPT | |
| SCHEMBL323109 | 0.80 | DYRK1A (0.49) | MAOBGAAALDH1A1SMN1; SMN2HDAC8 | |
| SCHEMBL8527442 | 0.80 | PDE4A (0.45) | LTA4HTSHRFFAR4ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | claimed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | claimed |