SCHEMBL6131987

SCHEMBL6131987

[c]1ccccc1-c1cccc(Oc2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.44
LTA4H P09960 1/20 0.43
TSHR P16473 1/20 0.43
GSTP1 P09211 1/20 0.42
AKR1C3 P42330 1/20 0.41
FFAR1 O14842 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39
KDR P35968 1/20 0.38
GAA P10253 2/20 0.38
MEN1 O00255 1/20 0.37
MITF O75030 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MAPT P10636 1/20 0.37
GFER P55789 1/20 0.37
KMT2A Q03164 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
NLRP1 Q9C000 1/20 0.37
NOD2 Q9HC29 1/20 0.37
P2RX3 P56373 1/20 0.37
HDAC8 Q9BY41 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315326 0.86 MAOB (0.44) MAOBLTA4HTSHRGSTP1AKR1C3
SCHEMBL360859 0.83 LTA4H (0.48) LTA4HTSHRGSTP1
SCHEMBL533385 0.82 DYRK1A (0.47) MAOBGAAALDH1A1MAPTSMN1; SMN2
SCHEMBL27574014 0.82 FFAR4 (0.41) LTA4HGSTP1FFAR1FFAR4GAA
SCHEMBL27574720 0.82 FFAR1 (0.39) MAOBGSTP1FFAR1FFAR4MEN1
SCHEMBL8074390 0.79 MAOB (0.51) MAOBGSTP1
SCHEMBL26567 0.79 MAOA (0.41) MEN1ALDH1A1KMT2AHDAC8DHODH
SCHEMBL589437 0.79 MAOA (0.41) MEN1ALDH1A1KMT2AHDAC8DHODH
SCHEMBL4218764 0.78 CYP1A2 (0.35) MAOBLTA4HGAAMAPT
SCHEMBL4078067 0.78 GRM5 (0.41) PRKDC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1435957-A4 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES VERTEX PHARMA (US) 2005-04-13 EP claimed
EP-1435957-A2 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES Vertex Pharmaceuticals Incorporated (US) 2004-07-14 EP claimed
WO-2002088078-A2 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3β PROTEIN AND PROTEIN COMPLEXES VERTEX PHARMACEUTICALS INCORPORATED (US) 2002-11-07 WO claimed