Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QDPR | P09417 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.44 |
| ▸ | USP7 | Q93009 | 4/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1979199 | 0.98 | QDPR (0.49) | QDPRCHRNB2CHRNA4HTR2CUSP7 | |
| SCHEMBL19249421 | 0.86 | TYR (0.48) | CHRNB2CHRNA4MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8313932 | 0.85 | QDPR (0.55) | QDPRCHRNB2CHRNA4HTR2CUSP7 | |
| Butylamine SCHEMBL28820128 | 0.84 | IKBKB (0.40) | QDPRHTR2CIKBKBMEN1CYP3A4 | |
| SCHEMBL3162433 | 0.82 | ALDH1A1 (0.43) | CHRNB2CHRNA4MEN1ALDH1A1CYP1A2 | |
| SCHEMBL29871375 | 0.82 | ALDH1A1 (0.43) | CHRNB2CHRNA4MEN1ALDH1A1CYP1A2 | |
| SCHEMBL24310183 | 0.81 | USP7 (0.52) | QDPRCHRNB2CHRNA4HTR2CUSP7 | |
| SCHEMBL12737660 | 0.81 | SLC6A2 (0.49) | QDPRCHRNB2CHRNA4HTR2CALDH1A1 | |
| SCHEMBL12656346 | 0.81 | SLC6A2 (0.52) | QDPRCHRNB2CHRNA4 | |
| SCHEMBL19347098 | 0.81 | HTR2C (0.58) | QDPRCHRNB2CHRNA4HTR2CUSP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650337-B2 | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-05-16 | — | — | US | claimed |
| EP-2956438-B1 | METHOD FOR SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE | GALDERMA RES & DEV (FR) | 2017-03-22 | — | — | EP | claimed |
| US-20150376126-A1 | METHOD FOR THE SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2015-12-31 | — | — | US | claimed |
| EP-2956438-A2 | METHOD FOR SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE | Galderma Research & Development (FR) | 2015-12-23 | — | — | EP | claimed |
| WO-2014125233-A2 | METHOD FOR SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2014-08-21 | — | — | WO | claimed |
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | claimed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | claimed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | claimed |
| JP-59029662-A | — | — | None | — | — | JP | disclosed |
| JP-59029662-A | — | — | None | — | — | JP | disclosed |
| JP-59029663-A | — | — | None | — | — | JP | disclosed |
| US-9650337-B2 | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-05-16 | — | — | US | disclosed |
| US-9650337-B2 | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-05-16 | — | — | US | disclosed |
| US-9650337-B2 | Method of synthesising 4-piperidin-4-yl-benzene-1,3-diol and the salts of same and novel compound tert-butyl 4-(2,4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2017-05-16 | — | — | US | disclosed |
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |
| JP-S5929662-A | 4-(2,4-DIHYDROXYPHENYL)PIPERIDINE COMPOUND AND ITS PREPARATION | MITSUI PETROCHEM IND LTD | 1984-02-16 | — | — | JP | disclosed |
| JP-S5929662-A | 4-(2,4-DIHYDROXYPHENYL)PIPERIDINE COMPOUND AND ITS PREPARATION | MITSUI PETROCHEM IND LTD | 1984-02-16 | — | — | JP | disclosed |
| JP-S5929663-A | 4-(2,4-DIHYDROXYPHENYL)-3,4-DEHYDROPIPERIDINE COMPOUND AND ITS PREPARATION | MITSUI PETROCHEM IND LTD | 1984-02-16 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376126-A1 | METHOD FOR THE SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE | HPD, CYP4B1, PAH | QDPR 28/4885CHRNB2 4287/4885CHRNA4 3651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.