Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316836 | 0.85 | NLRP3 (0.33) | SMN1; SMN2CYP3A4NLRP3MEN1KMT2A | |
| SCHEMBL8318325 | 0.82 | KMT2A (0.39) | SMN1; SMN2CYP3A4CYP2C9P2RX7KMT2A | |
| SCHEMBL8316807 | 0.82 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8875491 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP1A2CYP2C9CYP2C19P2RX7 | |
| SCHEMBL8313464 | 0.80 | NLRP3 (0.33) | SMN1; SMN2CYP1A2CYP2C9CYP2C19NLRP3 | |
| SCHEMBL8317735 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8312314 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8314698 | 0.78 | SMN1; SMN2 (0.35) | SMN1; SMN2CYP3A4P2RX7L3MBTL1MEN1 | |
| SCHEMBL8314030 | 0.77 | SMN1; SMN2 (0.36) | SMN1; SMN2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8312553 | 0.77 | ALDH1A1 (0.40) | SMN1; SMN2MEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |