Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317641 | 0.82 | EDNRA (0.52) | ALDH1A1SMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL8316197 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL8315915 | 0.80 | CDK2 (0.48) | ALDH1A1SMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL3842057 | 0.75 | CA12 (0.56) | ALDH1A1SMN1; SMN2LMNANPSR1MEN1 | |
| SCHEMBL8313217 | 0.74 | CDC7 (0.64) | ALDH1A1HTTMEN1KMT2ACDC7 | |
| SCHEMBL8316183 | 0.73 | KMT2A (0.45) | LMNAHTTMEN1KMT2AMAPT | |
| SCHEMBL8313727 | 0.71 | HSPD1 (0.59) | ALDH1A1SMN1; SMN2LMNAKMT2ACDC7 | |
| SCHEMBL8310859 | 0.68 | HSPD1 (0.59) | ALDH1A1SMN1; SMN2LMNAHTTMAPK1 | |
| SCHEMBL8311757 | 0.68 | EDNRA (0.72) | MEN1KMT2ATSHRHSD17B10HPGD | |
| SCHEMBL961193 | 0.68 | ENPP2 (0.54) | ALDH1A1SMN1; SMN2MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |