Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315672 | 0.82 | ALDH1A1 (0.46) | EDNRAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL8315398 | 0.81 | TXNRD1 (0.56) | EDNRAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8313728 | 0.81 | MEN1 (0.57) | EDNRAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL6764847 | 0.80 | PIK3CD (0.68) | ALDH1A1MAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL3842057 | 0.75 | CA12 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL6760774 | 0.74 | CDC7 (0.64) | ALDH1A1MAPTSMN1; SMN2HTTLMNA | |
| SCHEMBL8311524 | 0.73 | MEN1 (0.56) | EDNRAMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL7949358 | 0.72 | EDNRA (0.59) | EDNRAALDH1A1MAPTSMN1; SMN2MAPK1 | |
| SCHEMBL6314173 | 0.71 | ALDH1A1 (0.54) | EDNRAALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL8315471 | 0.71 | ALDH1A1 (0.56) | EDNRAALDH1A1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |