Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 6/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311757 | 0.74 | EDNRA (0.72) | KMT2AMEN1KDM4EHPGD | |
| SCHEMBL8315915 | 0.73 | CDK2 (0.48) | KMT2APTPN2PTPN1PTPN5MEN1 | |
| SCHEMBL8315672 | 0.73 | ALDH1A1 (0.46) | KMT2APTPN2PTPN1PTPN5MEN1 | |
| SCHEMBL8316197 | 0.70 | SMN1; SMN2 (0.50) | KMT2APTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL8313217 | 0.70 | CDC7 (0.64) | KMT2APTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL8313727 | 0.69 | HSPD1 (0.59) | KMT2APTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL8316242 | 0.69 | SMN1; SMN2 (0.54) | KMT2APOLBPKMMEN1MAPT | |
| SCHEMBL9750345 | 0.68 | GAA (0.54) | KMT2APTPN2PTPN1PTPN5HSPD1 | |
| SCHEMBL13629415 | 0.68 | MEN1 (0.57) | KMT2APTPN2PTPN1PTPN5HSPD1 | |
| Benzoic Acid SCHEMBL28546974 | 0.67 | TSHR (0.55) | MAPTLMNAHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| US-5726194-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-10 | — | — | US | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |